Associate Director, Musculoskeletal Therapeutic Area In Vivo Lead

Company: BIOMARIN
Location: Petaluma
Posted on: October 30, 2024

Job Description:

Musculoskeletal Therapeutic Area In Vivo Lead, Associate DirectorAbout the jobBioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives.The Job OpeningWe are seeking a highly motivated and agile Associate Director with experience in skeletal biology and disease to join our team as the Musculoskeletal Therapeutic (MSK) Area In Vivo Lead. The Associate Director will manage the portfolio of in vivo MSK studies across the Therapeutic Area as well as manage a team of in vivo staff focused on developing therapeutics for musculoskeletal diseases.This role reports into the Head of the Musculoskeletal Therapeutic Area with extensive interactions and partnership with the Head of Animal Resources. The successful candidate will advise on all in vivo aspects of the musculoskeletal research and early development portfolio. This role includes collaboration with external and internal scientists on research projects including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, diligence on business development opportunities, as well as application of in vivo methods and techniques. This role includes regular project management including study report writing for FDA filings, writing IACUC protocols, communicating scientific strategy and results to leadership, monitoring in vivo studies and collaborating with CROs, tissue collection, and sample management.The successful candidate will also have experience managing staff and be responsible for leading and developing the careers of a dynamic team of in vivo scientists while managing their allocation of effort in alignment with Research priorities. The ideal candidate will have a proven track record of managing a productive team, excellent communication skills, and commitment to developing leadership skills in themselves and others.Responsibilities:

• Effectively collaborate with both internal and external scientists on completion of musculoskeletal therapeutic area in vivo studies which includes CRO study placement/monitoring.
• Managing in vivo study projects including study design, sizing of cohorts, dosing, application of in vivo testing modalities, tissue collection, sample management, animal model selection, data analysis including statistics application, authoring study reports, and interpretation/presentation of scientific results.
• Provide projection on study project needs including budgeting, staffing, and scheduling.
• Align in vivo team priorities with the priorities of the MSK TA and Research.
• Execute hands-on responsibilities including animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection.
• Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment.
• With minimal guidance, collect, analyze, interpret, and present data within the Musculoskeletal Therapeutic group and across functional areas within the company.
• Communicate experimental plans and results to the leadership team. Support product development and regulatory filings for pivotal clinical studies.
• Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines.
• Must have excellent troubleshooting, organization, and planning skills, and the ability to work under timeline in a fast-paced environment.
• Excellent documentation skills including maintenance of daily records using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs.
• Willingness to work on site full time including off hours and weekends based on study needs.Staff Management and Training:
• Training technical staff on all aspects of in vivo study management.
• Oversight of in vivo technical staff performance of in vivo studies in the musculoskeletal therapeutic area.
• Provide developmental opportunities for in vivo technical staff to support their career growth.
• Responsible for scheduling of study technical staff to ensure timely completion of in vivo studies.
• Responsible for oversight of accuracy of technical staff data collection and analysis.General requirements for the position:
• Demonstrated experience in skeletal biology/disease or muscular biology/disease research in academia or industry (preferred) including publication record.
• Strong analytical, problem-solving, and decision-making skills.
• Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities.
• Excellent oral and written communication skills.
• Passion for contributing your scientific skills to develop therapies for patients in need.
• Must be able to utilize computer databases for analysis, data entry, and point of care observations.
• Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams.
• Must be able to regularly read, understand, verify accuracy, and document various written protocols, including Animal Care and Use Protocols and Standard Operating Procedures.
• Must be able to work with external regulatory agencies and accreditation groups.
• Some "off-core business hours" work required.Education and Experience Requirements:
• PhD in a related subject area with demonstrated research experience in skeletal biology.
• Postdoctoral or previous industry experience in skeletal biology (7+years).
• Extensive hands-on experience with rodent in vivo work.
• Previous in vivo staff management experience.This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA.We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.In the U.S., the salary range for this position is $150,400 to $225,600 per year, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
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Keywords: BIOMARIN, Mountain View , Associate Director, Musculoskeletal Therapeutic Area In Vivo Lead, Executive , Petaluma, California